Neuroprotective effects ofethanolic extract against rotenone-induced neurodegeneration and motor impairments in mouse model.

Abstract

formulations impart neuroprotective properties against dementia, oxidative stress and mitochondrial impairments. The current study aimed to evaluate the neuroprotective potential of ethanolic extract of(EMA) on motor impairments. GC-MS characterization of extract revealed active ingredients. Adult mice were exposed to rotenone to induce neurodegeneration and motor dysfunctions. EMA reduced striatal dopamine depletion and motor impairment. Candidate genes for anti-oxidant enzymes, dopamine transmission, synaptogenesis and mitochondrial regulator were significantly modulated in EMA exposed mice. Collectively, EMA imparted preventive action against rotenone-mediated brain damage, augmented antioxidant capabilities and prevented motor dysfunctions. It is suggested that MA as a potential medicinal plant for development of protective strategies in relevant clinical applications.