Peer-reviewed veterinary case report
Neuroprotective potential of glibenclamide is mediated by antioxidant and anti-apoptotic pathways in intracerebral hemorrhage.
- Journal:
- Brain research bulletin
- Year:
- 2018
- Authors:
- Zhou, Fangfang et al.
- Affiliation:
- Department of Neurology · China
- Species:
- rodent
Abstract
The sulfonylurea receptor 1 (SUR1)-regulated NCchannels were progressively upregulated and demonstrated unchecked opening in central nervous system (CNS) injury, which induced cerebral damage. Glibenclamide (GLI) can block NCchannels and consequently exert protective effects. Recent studies have found that GLI has antioxidative effects. In this study, we primarily explored the antioxidative effects of GLI in a rat model of intracerebral hemorrhage (ICH). We found that GLI could scavenge free radicals, reduce activated-caspase-3 expression, increase the Bcl-2/Bax ratio, inhibit apoptosis, and improve functional neurological outcomes in a rat model of ICH.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29933037/