Peer-reviewed veterinary case report
Neutrophil myeloperoxidase levels in dogs with babesiosis
By Celliers, Anri et al.·Published in Frontiers in veterinary science·2020·Department of Companion Animal Clinical Studies·View original on PubMed →
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Original publication title: Neutrophil Myeloperoxidase Index in Dogs With Babesiosis Caused by.
- Species:
- dog
Plain-English summary
A group of 140 dogs with babesiosis, a serious tick-borne infection, showed higher levels of a specific immune marker called the neutrophil myeloperoxidase index (MPXI) compared to healthy dogs. This study found that dogs who did not survive the infection had even higher MPXI levels, which were linked to various inflammatory substances in their blood. The findings suggest that MPXI could help veterinarians assess the severity of babesiosis and predict outcomes for affected dogs. Further research is needed to confirm its usefulness as a marker for inflammation and prognosis in these cases.
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Abstract
Babesiosis caused by the virulent tick-borne hemoprotozoan,, results in a marked systemic inflammatory host response in dogs. Neutrophils form part of the innate immune response and contains myeloperoxidase (MPO) as the predominant component of the neutrophil lysosomal protein in azurophilic granules. The neutrophil myeloperoxidase index (MPXI), determined on the ADVIA hematology analyzer, is a quantitative estimate of intracellular MPO content. Objectives of this study were to: (a) compare MPXI in dogs with babesiosis with healthy control dogs; (b) compare MPXI in dogs that died from babesiosis with dogs that survived and controls; and (c) correlate the MPXI with the previously determined segmented and band neutrophil count and cytokine concentrations in dogs with babesiosis. Data for 140 dogs naturally infected withand 20 healthy control dogs were retrospectively evaluated. Neutrophil counts and MPXI were determined on an ADVIA 2120 analyzer. Cytokine concentrations [interleukin (IL)-2, IL-6, IL-8, IL-10, IL-18, granulocyte-macrophage colony stimulating factor (GM-CSF), and monocyte chemo-attractant protein-1 (MCP-1)] were determined using a canine-specific multiplex immunoassay. The mortality rate of thedogs was 11% (15/140). MPXI was significantly higher indogs (= 0.033), and innon-survivors (= 0.011), compared with healthy control dogs. Indogs a significant positive correlation was found between MPXI and IL-10 (= 0.211,= 0.039) and a significant negative correlation was found between MPXI and IL-8 (= -0.350,< 0.001). Innon-survivors, significant positive correlations were found between MPXI and IL-2 (= 0.616= 0.033), IL-6 (= 0.615,= 0.033), IL-18 (= 0.613,= 0.034), GM-CSF (= 0.630,= 0.028), and MCP-1 (= 0.713,= 0.009). Insurvivors, a significant negative correlation was found between MPXI and IL-8 (= -0.363,= 0.001). MPXI was correlated with pro-inflammatory cytokines indogs that died. The potential of MPXI as a novel marker of inflammation and prognosis in dogs infected with, thus warrants further investigation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32133380/