Peer-reviewed veterinary case report
Blood test ratios linked to inflammation in dogs with mitral valve
By Kocaturk, Meriç et al.·Published in Veterinary research communications·2024·Department of Internal Medicine·View original on PubMed →
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Original publication title: Neutrophil-to-lymphocyte ratio and red blood cell distribution width to platelet ratio and their relationships with inflammatory and antioxidant status in dogs with different stages of heart failure due to myxomatous mitral valve disease.
- Species:
- dog
Plain-English summary
A group of dogs with heart failure due to myxomatous mitral valve disease was studied to understand how certain blood cell ratios relate to their condition. Researchers found that the neutrophil-to-lymphocyte ratio (NLR) increased, while the red blood cell distribution width-to-platelet ratio (RDW/PLT) decreased in dogs with more severe heart failure compared to healthy dogs. These blood ratios could help veterinarians monitor the severity of heart failure and the effectiveness of treatments. Although no significant changes were noted after treatment, the study suggests these blood indices may be useful in managing heart failure in dogs.
People also search for: dog heart failure symptoms · neutrophil-to-lymphocyte ratio in dogs · heart disease treatment for dogs
Abstract
We aimed to evaluate the red blood cell distribution width-to-platelet ratio (RDW/PLT) with other complete blood cell count (CBC) indices and their correlations with serum proinflammatory cytokines, acute phase proteins (APPs), and antioxidant biomarkers in dogs at different stages of heart failure (HF). A total of 29 dogs were divided into four groups according to the ACVIM Consensus Statement: stage-A (healthy/controls, n = 8), stage-B2 (n = 6), stage-C (n = 10), and stage-D (n = 5). Seventeen CBC indices were calculated and correlated with the measurements of inflammatory, APPs, and antioxidant biomarkers, as well as selected echocardiographic variables in all dogs. At stage-C, CBC indices were evaluated 14 days after the treatment. Statistically significant changes were observed only for RDW/PLT and neutrophil-to-lymphocyte ratio (NLR) between groups. NLR increased, but RDW/PLT deceased in dogs with HF, compared to controls (P < 0.05). There were no statistically differences between pre- and post-treatment CBC indices. There were significantly positive and negative correlations between the CBC indices, serum parameters and selected echocardiographic variables in dogs with HF(P < 0.05). ROC analysis showed the best sensitivity (57% and 68%) and specificity (100% and 57%) for NLR > 5.8 and RDW/PLT ≤ 0.057 for predicting the severity of HF, respectively. Results showed that NLR and RDW/PLT may have potential for monitoring severity of the disease and the effect of treatment in dogs with HF. Imbalances between indices of circulating blood cells can contribute to immunoinflammatory and antioxidant responses in pathogenesis of canine HF, which may provide us alternative targets to develop new diagnostic and therapeutic strategies in veterinary medicine.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38849636/