Peer-reviewed veterinary case report
High neutrophil count linked to worse outcomes in dogs
By Breheny, Craig R et al.·Published in The Veterinary record·2020·Hospital for Small Animals, United Kingdom·View original on PubMed →
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Original publication title: Neutrophilia is associated with a poorer clinical outcome in dogs with chronic hepatitis.
- Species:
- dog
Plain-English summary
A group of dogs with chronic hepatitis (liver disease) was studied to see how their blood cell counts affected their chances of recovery. It was found that dogs with high levels of neutrophils (a type of white blood cell) had a shorter survival time compared to those with lower levels. This suggests that if a dog has elevated neutrophils when diagnosed, it may indicate a poorer prognosis. Understanding this connection could help veterinarians better predict outcomes for dogs with chronic hepatitis in the future.
People also search for: dog liver disease symptoms · chronic hepatitis in dogs · high neutrophils in dogs treatment
Abstract
BACKGROUND: Liver disease is a common cause of morbidity and mortality in dogs. Currently, it is challenging to prognosticate in these cases. The aim of this study was to evaluate the utility of the haematological variables in dogs with chronic hepatitis. METHODS: Dogs with chronic hepatitis confirmed on histopathology had presenting haematological values retrospectively obtained and evaluated against survival time. Eighty-two dogs met the inclusion criteria and their data analysed. RESULTS: Neutrophilic patients, with a count greater than 12×10/l, controlled for sex and age, had a shorter survival time (P≤0.01). In dogs, neutrophilia at presentation predicted a poor outcome, whereas the other haematological parameters were not prognostically informative. When the dogs were split into even quarters on the basis of their neutrophil count, those within the higher quartiles had poorer survival times. Neutrophilia was associated with a poorer survival time in comparison to those patients with a lower count. CONCLUSION: The relationship between neutrophils, inflammation and clinical outcome is deserving of future study in dogs with chronic hepatitis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31974266/