Peer-reviewed veterinary case report
Dog with severe skin lesions and blood disorders after carprofen
By Mellor, P J et al.·Published in The Journal of small animal practice·2005·Queen's Veterinary School Hospital, United Kingdom·View original on PubMed →
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Original publication title: Neutrophilic dermatitis and immune-mediated haematological disorders in a dog: suspected adverse reaction to carprofen.
- Species:
- dog
Plain-English summary
A young dog suddenly developed severe skin lesions and collapsed, prompting a visit to the vet. Tests showed that the dog had a serious skin condition called neutrophilic dermatitis, along with immune-mediated hemolytic anemia (where the body destroys its own red blood cells) and low platelet counts. The vet suspected that the dog's reaction was due to a medication called carprofen, which is commonly used for pain relief. After ruling out two antibiotics as potential causes, the dog was treated for the adverse reaction and is now recovering.
People also search for: dog skin problems after carprofen · dog collapse and skin lesions · immune-mediated anemia treatment in dogs
Abstract
This report describes the clinical and pathological findings of a suspected idiosyncratic adverse drug reaction in a young dog. The patient presented with sudden onset, severe skin lesions together with episodes of collapse. Investigations revealed a neutrophilic dermatitis with vasculitis, immune-mediated haemolytic anaemia and thrombocytopenia. Similar pathology has been described in human cases of Sweet's syndrome. The chronology of events suggested an adverse drug reaction to carprofen, although two antibiotics had been prescribed within the dog's recent history. Lymphocyte transformation tests were performed and tended to exclude both antibiotics as the cause of the reaction. To the authors' knowledge, lymphocyte transformation tests have not previously been described with regard to drug hypersensitivity assessment in the veterinary literature, and this is the first peer-reviewed case report of neutrophilic dermatitis and vasculitis with immune-mediated haemolytic anaemia and thrombocytopenia occurring as a suspected adverse drug reaction to carprofen in the dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15909447/