New evidence for tamoxifen as an antischistosomal agent:,and target fishing studies.

Abstract

Praziquantel is the only drug available to treat schistosomiasis, and there is an urgent demand for new anthelmintic agents.We conducted in-depthand&#xa0;studies and report a target fishing investigation., tamoxifen was active against adult and immature worms at low concentrations (<5&#xa0;&#x3bc;M). Tamoxifen at a single dose (400&#xa0;mg/kg) or once daily for five consecutive days (100&#xa0;mg/kg/day) in mice harboring either adult (patent infection) or juvenile (prepatent infection) significantly reduced worm burden (30-70%) and egg production (70-90%). Target fishing studies revealed propionyl-CoA carboxylase as a potential target for tamoxifen in&#xa0;and glucose uptake bywas also significantly reduced.Our results provide news evidence of antiparasitic effect of tamoxifen and reveal propionyl-CoA carboxylase as a potential target.