Peer-reviewed veterinary case report
New furoxan derivatives for the treatment of ocular hypertension.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2017
- Authors:
- Blangetti, Marco et al.
- Affiliation:
- Dipartimento di Scienza e Tecnologia del Farmaco - Università · Italy
- Species:
- rabbit
Abstract
A small series of water-soluble NO-donor furoxans bearing a basic center at the 4-position, having a wide lipophilic-hydrophilic balance range, and endowed with different NO-release capacities, were synthesized and characterized. Selected members were studied for their IOP-lowering activity in the transient ocular hypertensive rabbit model at 1% dose. The most effective IOP-lowering products were compounds 3 and 7, whose activity 60min after administration was similar to that of Timolol. Notably, 7 was characterized by a long-lasting action. The IOP-lowering activity in this series of products appeared to be modulated by the lipophilic-hydrophilic balance rather than by the NO-donor capacity.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28027869/