Peer-reviewed veterinary case report
New mechanisms highlight the complex relationship of Apolipoprotein E and tau pathogenesis.
- Journal:
- Neuron
- Year:
- 2025
- Authors:
- Chakrabarty, Paramita & Angelle, Conner
- Affiliation:
- University of Florida · United States
Abstract
A rare variant of Apolipoprotein E3 with neuroprotective properties has been identified in autosomal-dominant Alzheimer's disease. In this issue of Neuron, Chen et al.show that direct interaction between this variant and tau blocks tau pathogenesis in rodent models.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40049146/