Peer-reviewed veterinary case report
New roles revealed for T cells and DCs in glomerulonephritis.
- Journal:
- The Journal of clinical investigation
- Year:
- 2009
- Authors:
- Kim, Alfred H J et al.
- Affiliation:
- Department of Internal Medicine · United States
Abstract
Little is known about the potential role of T cells in the inflammatory renal disease glomerulonephritis (GN). GN has been historically viewed as a product of immune complex-mediated complement activation, and the presence of autoantibodies made identifying T cell-specific effector contributions difficult to elucidate. In this issue of the JCI, Heymann et al. generate what they believe to be a novel, transgenic murine model of GN, demonstrating a direct role for CD8+ T cells, activated CD4+ T cells, and DCs in the pathogenesis of GN (see the related article beginning on page 1286).
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19422093/