Peer-reviewed veterinary case report
How to tell types of fluid in dogs' chest using protein tests
By Zoia, A et al.·Published in Veterinary clinical pathology·2024·San Marco Veterinary Clinic, Italy·View original on PubMed →
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Original publication title: New strategies to classify canine pleural effusions and the diagnostic value of acute phase proteins, amylase, and adenosine deaminase in pleural exudates.
- Species:
- dog
Plain-English summary
A group of 68 dogs with fluid buildup in their chest (pleural effusion) were tested to see how well different methods could tell if the fluid was due to infection, cancer, or other causes. The best method was the simplified Light's criteria, which accurately identified the type of fluid in nearly all cases. Other tests, like measuring certain proteins and enzymes in the fluid, were less effective. The study found that lower levels of a specific enzyme (PON-1) in the fluid could indicate cancer as the cause of the effusion.
People also search for: dog pleural effusion causes · dog fluid in chest treatment · how to tell if dog has cancer
Abstract
BACKGROUND: In dogs, simplified Light's criteria can discriminate transudates from exudates. Other tests used in human medicine are pleural effusion cholesterol (CHOL) and butyrylcholinesterase [BChE], the pleural effusion/serum ratio of these analytes (CHOLand BChE), and the serum albumin minus pleural effusion albumin gradient (SEAG). OBJECTIVES: We aimed to assess the diagnostic accuracies of different biomarkers in dogs with pleural effusion in differentiating exudates from transudates. Secondarily, we evaluated the potential diagnostic utility of pleural effusion acute phase proteins, amylase, and adenosine deaminase in discriminating causes of exudative effusions. METHODS: Cross-sectional study including 68 client-owned dogs with pleural effusion. RESULTS: There were 48 exudates (10 septic, 16 neoplastic, 9 hemorrhagic, and 13 classified as other exudates) and 20 transudates. All the variables analyzed, except SEAG, were significantly different between exudates and transudates. Using the cut-off values adopted in human literature, accuracies for CHOL, CHOL, BChE, and BChEwere between 82.35% and 85.29%; all values were significantly lower compared with the previously published simplified Light's criteria accuracy (i.e., 98%, p < .001 for all comparisons). We found the accuracy of the simplified Light's criteria to be similar to what has been previously reported (95.59%, p = .238). Paraoxonase-1 (PON-1) activity and the pleural effusion/serum paraoxonase-1 ratio (PON-1) were significantly lower in exudative neoplastic effusions than in exudative hemorrhagic (p = .004 and p = .001) and septic (p = .004 and p < .001) effusions. CONCLUSION: Simplified Light's criteria were the best method for discriminating transudates from exudates, and a low PON-1activity and PON-1in exudative effusions may suggest an underlying neoplasia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39434423/