Peer-reviewed veterinary case report
New test for endothelin receptor type B (EDNRB) mutation genotyping in horses.
- Journal:
- Molecular and cellular probes
- Year:
- 2016
- Authors:
- Ayala-Valdovinos, Miguel Angel et al.
- Affiliation:
- Departamento de Producció
- Species:
- horse
Abstract
Lethal white foal syndrome (LWFS) is an autosomal recessive disease of neonatal foals characterized by a white hair coat and a functional intestinal obstruction. Traditional techniques for identifying the dinucleotide mutation (TC→AG) of the endothelin receptor B gene (EDNRB) associated with LWFS are time-consuming. We developed a new technique based on mutagenically separated polymerase chain reaction (MS-PCR) for simple detection of the EDNRB genotype in horses.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27039359/