Peer-reviewed veterinary case report
NFATc3 deficiency may contribute to the development of mammary gland adenocarcinoma in aging female mice.
- Journal:
- Molecular carcinogenesis
- Year:
- 2005
- Authors:
- Lee, Hoyun et al.
- Affiliation:
- Northeastern Ontario Regional Cancer Centre · Canada
- Species:
- rodent
Abstract
The nuclear transcription factor of activated T cells (NFAT) suggested to be a tumor suppressor. Here we report that two out of three NFATc3-/- and two in four NFATc3 +/- female mice developed aggressive mammary adenocarcinoma by 12.5 and 16 mo of age, respectively, with no occurrences in age-matched wild-type littermates (N-14). Thus, our data suggest that NFATc3 can suppress the development of mammary gland tumors in female mice.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16167349/