Peer-reviewed veterinary case report
Nicotine attenuates spatial learning deficits induced in the rat by perinatal lead exposure.
- Journal:
- Brain research
- Year:
- 2004
- Authors:
- Zhou, Mingfu & Suszkiw, Janusz B
- Affiliation:
- Department of Molecular and Cellular Physiology · United States
- Species:
- rodent
Abstract
Maternally lead (Pb)-exposed, juvenile rats exhibit significant deficits in spatial reference memory acquisition and working memory performance in the Morris water maze (MWM). Acute systemic application of nicotine reverses these deficits without affecting behavioral performance of the age-matched, lead-unexposed control animals. These results suggest that nicotinic agonist treatments can ameliorate learning and memory impairments, presumably by compensating for deficient nicotinic function in developmentally lead-exposed animals.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/14746932/