Peer-reviewed veterinary case report
No herpesvirus found in West Highland white terriers with lung
By Roels, E et al.·Published in Veterinary pathology·2016·Department of Clinical Sciences·View original on PubMed →
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Original publication title: No Evidence of Herpesvirus Infection in West Highland White Terriers With Canine Idiopathic Pulmonary Fibrosis.
- Species:
- dog
Plain-English summary
A group of West Highland White Terriers with a serious lung condition called canine idiopathic pulmonary fibrosis (CIPF) were tested for herpesvirus infection to see if it might be causing their symptoms. Researchers took lung and blood samples from 28 affected dogs and 18 healthy dogs but found no evidence of herpesvirus in any of the samples. This suggests that herpesvirus is not linked to CIPF in these dogs, and further research is needed to explore other possible causes of this lung disease.
People also search for: West Highland White Terrier lung disease · canine idiopathic pulmonary fibrosis causes · dog herpesvirus infection symptoms
Abstract
In humans, horses, and rodents, an association between pulmonary fibrotic disorders and gammaherpesvirus infection has been suggested. In dogs, canine idiopathic pulmonary fibrosis (CIPF), a progressive fibrotic lung disease of unknown origin and poorly understood pathophysiology, has been reported to occur in West Highland white terriers (WHWTs). The present study investigated the potential association between CIPF and herpesvirus infection. A PCR assay, using a mixture of degenerate and deoxyinosine-substituted primers targeting highly conserved regions of the DNA polymerase gene (DPOL) of herpesviruses, was applied on both lung and blood samples from WHWTs affected with CIPF and controls. Herpesvirus DPOL sequence could not be amplified from any of 46 lung samples (28 affected WHWTs and 18 control dogs of various breeds) and 38 blood samples (19 CIPF WHWTs and 19 control age-matched WHWTs) included. An association between CIPF and herpesvirus infection is therefore unlikely. Investigation of other causes of the disease is warranted.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27106742/