Peer-reviewed veterinary case report
No STINGs attached: How APOE-Christchurch dampens Alzheimer's pathology.
- Journal:
- Immunity
- Year:
- 2025
- Authors:
- Akay, Leyla Anne & Tsai, Li-Huei
- Affiliation:
- Picower Institute for Learning and Memory · United States
Abstract
The "Christchurch" protective variant in the APOE gene has recently been identified, but its mechanisms of action remain unknown. In this issue of Immunity, Naguib and Lopez-Lee et al. provide evidence for the APOE-Christchurch variant suppressing microglial cGAS-STING responses and increasing clearance of pathological tau aggregates in mouse models of Alzheimer's disease.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40803311/