Peer-reviewed veterinary case report
Nodular skin lumps in a golden retriever without kidney tumor or gene
By Zanatta, M et al.·Published in Journal of comparative pathology·2013·Department of Veterinary Medical Sciences, Italy·View original on PubMed →
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Original publication title: Nodular dermatofibrosis in a dog without a renal tumour or a mutation in the folliculin gene.
- Species:
- dog
Plain-English summary
A 10-year-old female golden retriever was brought to the vet because she had many firm lumps on her skin, which were up to 4 cm in size. After tests, the vet confirmed she had a rare skin condition called nodular dermatofibrosis, but scans showed her kidneys were healthy and there were no tumors. The dog underwent surgery to remove her uterus due to prolonged heat cycles, and further examinations revealed no issues with her ovaries. Over five years of follow-up, her kidney health remained stable, and no genetic mutations were found.
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Abstract
Canine nodular dermatofibrosis is a rare skin disease associated with renal cystadenoma or cystadenocarcinoma and uncommonly with uterine leiomyoma. It is generally seen in German shepherd dogs, but has been also reported in other breeds, and a relationship has been suggested with mutation of the gene encoding folliculin (FLCN), which is located on chromosome 5. A 10-year-old female golden retriever was presented because of numerous firm cutaneous nodules up to 4 cm in diameter over the entire body surface. Cytological and histopathological examinations confirmed generalized cutaneous nodular dermatofibrosis, but ultrasonography of both kidneys ruled out renal neoplasia. Ovariohysterectomy was performed because of prolonged oestrus periods. Microscopical examination of the excised tissues confirmed the absence of uterine neoplasia, but identified rete adenoma of the right ovary. Abdominal ultrasound performed repeatedly over a 5-year follow-up period did not identify any alteration in the renal parenchyma. Molecular studies excluded the presence of any mutation in the FLCN gene.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22871425/