Peer-reviewed veterinary case report
Rectal nodules in dogs that can mimic cancer but are benign lymphoid
By Stent, Andrew W et al.·Published in Veterinary pathology·2024·The University of Melbourne, Australia·View original on PubMed →
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Original publication title: Nodular hyperplasia of lymphoglandular complexes in dogs: A potential diagnostic pitfall for rectal masses.
- Species:
- dog
Plain-English summary
A 5-year-old male Beagle and a 7-year-old male Labrador were brought to the vet due to straining to defecate (tenesmus) and passing blood in their stool (hematochezia). After examining and removing the rectal masses, tests showed that these growths were made up of lymphoid tissue, which is part of the immune system. The diagnosis was nodular hyperplasia of lymphoglandular complexes, a rare condition in dogs. Both dogs were treated successfully after the masses were excised, and they recovered well.
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Abstract
Lymphoglandular complexes are components of the gut-associated lymphoid tissue that are characterized by submucosal lymphoid aggregates invested by projections of mucosal epithelium. Reports of pathology involving these structures are rare in both human and veterinary literature. Here, the authors report 2 cases of rectal masses excised from dogs following a period of tenesmus and hematochezia. In both animals, the masses were composed of lymphoid tissue closely encompassing tubuloacinar structures. Immunohistochemistry and polymerase chain reaction antigen receptor rearrangement testing demonstrated that the lymphoid population was polyclonal, comprising T and B cells arranged in loosely follicular aggregates centered on the epithelial foci. In light of these findings, a diagnosis of lymphoglandular complex nodular hyperplasia was reported. To the authors' knowledge, this is the first report of this condition in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37547933/