Peer-reviewed veterinary case report
Dog with corneal nodule after chronic superficial keratitis
By Ziółkowska, Natalia et al.·Published in Veterinary Ophthalmology·2025·Department of Histology and Embryology, Faculty of Veterinary Medicine University of Warmia and Mazury in Olsztyn Olsztyn Poland·View original on Crossref →
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Original publication title: Nodular Keratitis Associated With a Previous Diagnosis of Chronic Superficial Keratitis in a German Shepherd Dog: A First Case Report
- Species:
- dog
Plain-English summary
A German Shepherd dog with a history of chronic superficial keratitis (a long-term eye condition) developed a non-painful, round nodule on its cornea. After a thorough eye exam, the vet initially tried treating it with a topical steroid, but this did not help. The dog then underwent a minor surgical procedure to remove the nodule, which was later examined under a microscope. The findings showed that the nodule was made up of various immune cells, indicating inflammation. The dog was treated successfully, and the nodule was removed, which should help improve its eye health.
People also search for: dog eye problems · German Shepherd corneal nodule treatment · chronic superficial keratitis in dogs
Abstract
ABSTRACT Objective To describe the clinical and morphological features of a case of superficial nodular keratitis in a dog. Case Description A German shepherd dog previously diagnosed with chronic superficial keratitis (CSK) presented with a nonpainful, unilateral corneal nodule. After a complete ophthalmic examination, topical treatment with dexamethasone (0.1% dexamethason, WZW) was prescribed. However, the patient did not respond to this treatment; thus, a superficial keratectomy was performed. The lesion was examined histologically and immunohistochemically. Results The ophthalmic examination revealed a round, pink, solid nodule, approximately 0.5 cm in diameter, located in the ventral, paracentral cornea. Results from the Schirmer tear test I , tonometry, and fluorescein staining were in the normal ranges. A small amount of mucous discharge and moderate hyperemia of the bulbar conjunctiva were present. The histological examination revealed a solid mass in the superficial corneal stroma under the corneal epithelium. Hematoxylin and eosin (HE) staining showed that the mass was supplied with blood vessels; HE and immunohistochemistry revealed it consisted of a mixture of plasma cells (MUM + cells), B lymphocytes (CD79 + , CD20 + cells), T lymphocytes (CD3 + ), and macrophages (Iba1 + cells). Mitotic figures were absent. Some nuclei in inflammatory infiltrates displayed a Ki76 + reaction. Inflammatory infiltrates were present in the superficial stroma and the corneal epithelium. Conclusion These novel results demonstrate that the features of nodular keratitis in a German shepherd dog previously diagnosed with CSK differ from the features of xanthogranulomas, nodular episcleritis, corneal granulomas, pyogranulomatous keratitis, corneal epithelial inclusion cysts, protozoal keratitis, and corneal squamous cell carcinoma.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/vop.70009