Peer-reviewed veterinary case report
Dog with brain tumor treated by electroporation and radiation therapy
By Garcia, P A et al.·Published in Technology in cancer research & treatment·2011·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Non-thermal irreversible electroporation (N-TIRE) and adjuvant fractionated radiotherapeutic multimodal therapy for intracranial malignant glioma in a canine patient.
- Species:
- dog
Plain-English summary
A dog with an inoperable brain tumor was treated with a new technique called non-thermal irreversible electroporation (N-TIRE) to reduce the tumor size and relieve pressure in the brain. This treatment helped improve the dog's neurological function enough to allow for follow-up radiation therapy. Although the dog achieved complete remission of the tumor, it sadly passed away 149 days later due to complications from radiation treatment. Overall, this case suggests that N-TIRE could be a valuable option for dogs with difficult-to-treat brain tumors, potentially offering similar survival times as traditional surgery and radiation.
People also search for: dog brain tumor treatment · N-TIRE for dogs · canine glioma therapy · dog radiation therapy side effects
Abstract
Non-thermal irreversible electroporation (N-TIRE) has shown promise as an ablative therapy for a variety of soft-tissue neoplasms. Here we describe the therapeutic planning aspects and first clinical application of N-TIRE for the treatment of an inoperable, spontaneous malignant intracranial glioma in a canine patient. The N-TIRE ablation was performed safely, effectively reduced the tumor volume and associated intracranial hypertension, and provided sufficient improvement in neurological function of the patient to safely undergo adjunctive fractionated radiotherapy (RT) according to current standards of care. Complete remission was achieved based on serial magnetic resonance imaging examinations of the brain, although progressive radiation encephalopathy resulted in the death of the dog 149 days after N-TIRE therapy. The length of survival of this patient was comparable to dogs with intracranial tumors treated via standard excisional surgery and adjunctive fractionated external beam RT. Our results illustrate the potential benefits of N-TIRE for in vivo ablation of undesirable brain tissue, especially when traditional methods of cytoreductive surgery are not possible or ideal, and highlight the potential radiosensitizing effects of N-TIRE on the brain.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21214290/