Peer-reviewed veterinary case report
Cat with kidney disease from rare fibrillary deposits in glomeruli
By Cavana, P et al.·Published in Veterinary pathology·2008·Department of Animal Pathology, Italy·View original on PubMed →
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Original publication title: Noncongophilic fibrillary glomerulonephritis in a cat.
- Species:
- cat
Plain-English summary
A 5-year-old female European cat was brought to the vet with symptoms of nephrotic syndrome, which included swelling and changes in urination. Tests showed high protein levels in her urine and low protein levels in her blood, indicating kidney issues. A closer examination revealed a specific type of kidney disease called nonamyloidotic fibrillary glomerulonephritis, which is rare in cats. While the report does not detail treatment outcomes, identifying the condition is crucial for managing her health.
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Abstract
This report describes an uncommon case of nonamyloidotic fibrillary glomerulonephritis. A 5-year-old female European cat was presented with nephrotic syndrome. Serum biochemistry and urinalysis revealed a mild increase in cholesterol, low total protein, severe hypoalbuminemia, and high proteinuria with a high protein-to-creatinine ratio. An histologic examination revealed an interstitial nephritis and a diffuse glomerulonephritis, with multifocal thickening of the Bowman's capsule. Transmission electron microscopy showed widespread fibrillary deposits in the glomerular basement membrane and in the mesangium. These fibrils ranged between 18 and 26 nm in diameter and were Congo red negative, which allowed their differentiation from amyloid. Immunohistochemistry demonstrated expression for immunoglobulin M (IgM) and immunoglobulin G (IgG) within the mesangium. Renal deposits of Congo red-negative amyloid-like fibrils have been described in humans, horses, monkeys, and dogs. This is the first report of noncongophilic fibrillary glomerulopathy in a cat.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18487491/