Peer-reviewed veterinary case report
Dog with brain inflammation from Aujeszky disease virus infection
By Schöniger, S et al.·Published in Veterinary pathology·2012·Institute of Pathology, Germany·View original on PubMed →
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Original publication title: Nonsuppurative encephalitis in a dog.
- Species:
- dog
Plain-English summary
A 4-year-old male German Hunting Terrier showed serious symptoms including tremors, breathing problems, and muscle spasms, and sadly passed away despite intensive care. Before these severe signs, the dog had been vomiting and had diarrhea. Tests revealed that the dog had a brain infection caused by the Aujeszky disease virus, which is typically found in wild boar. Unfortunately, the treatment was not successful, and the dog did not survive.
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Abstract
A 4-year-old male German Hunting Terrier presented with tremor, dyspnea, trismus, spasms of the musculature of the larynx and pharynx, and hypothermia and subsequently died despite intensive clinical care. Prior clinical signs included vomitus and diarrhea. Microscopic examination of the brain revealed a multifocal nonsuppurative brain stem encephalitis; a few intralesional neurons contained intranuclear inclusions. By immunohistochemistry, Aujeszky disease virus (Suid herpesvirus 1) antigen was detected in neurons in the brain and in ganglion cells of the trigeminal ganglia. Viral culture of brain tissue confirmed the presence of Aujeszky disease virus. Histopathologic findings in the brain with the identification of Aujeszky disease virus by immunohistochemistry and polymerase chain reaction are consistent with Aujeszky disease virus-induced encephalitis. Sequencing revealed a 100% homology of the isolated Aujeszky disease virus with Aujeszky disease virus isolates of wild boar from Eastern Germany.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22308232/