Peer-reviewed veterinary case report
Novel anti-infection agents: small-molecule inhibitors of bacterial transcription factors.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2007
- Authors:
- Bowser, Todd E et al.
- Affiliation:
- Paratek Pharmaceuticals · United States
Abstract
Structure-based drug design was utilized to identify potent small-molecule inhibitors of proteins within the AraC family of bacterial transcription factors, which control virulence in medically important microbes. These agents represent a novel approach to fight infectious disease and may be less likely to promote resistance development. These compounds lack intrinsic antibacterial activity in vitro and were able to limit a bacterial infection in a mouse model of urinary tract infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17766109/