Peer-reviewed veterinary case report
Electrochemotherapy with nasal cavity immersion treats dog nasal
By Suzuki, Daniela O H et al.·Published in Artificial organs·2017·Institute of Biomedical Engineering·View original on PubMed →
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Original publication title: Novel application for electrochemotherapy: Immersion of nasal cavity in dog.
- Species:
- dog
Plain-English summary
A dog with nasal tumors underwent surgery to remove most of the cancerous mass, but some tumor remained in the nasal cavity. To help eliminate the remaining tumor, veterinarians used a treatment called electrochemotherapy, which involves applying an electric field to enhance the effectiveness of chemotherapy drugs. They immersed the dog's nasal cavity in a special solution containing the chemotherapy drug bleomycin before applying the electric field. This innovative approach showed promising results in effectively targeting the tumor tissue. The treatment was successful in eliminating the remaining cancer in the nasal cavity.
People also search for: dog nasal tumor treatment · electrochemotherapy for dogs · bleomycin nasal cancer dog
Abstract
Electrochemotherapy is a new modality of local cancer treatment that increases the delivery of chemotherapy drugs into tumor cells by applying intense electric fields. This novel electrochemotherapy application was applied as an adjuvant to surgery and eliminated intranasal tumors in dog. The treatment challenges are the surgery limitations due to anatomy and residual tumor in the bone cavity. Most of the tumoral mass on nasal cavity was surgically removed. The internal nasal cavity was immersed in liquid and bleomycin before applying electric field. The solution was necessary to increase the superficial contact between plate electrodes and residual tumor. The numerical study demonstrated electrochemotherapy efficiency in different clinical situations. The proximity between electrodes and bone (<3 mm) and bone irregularities affect the electric field distribution on tumoral tissue. The tumoral tissue around bone protuberances tends to be eliminated. Electrochemotherapy with plate electrodes inside the cavity might not be effective. Different values of electric conductivity solution were studied; the ideal value was 0.5 S/m. The numerical and experimental results confirm the successful application of electrochemotherapy on dog nasal cavity.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28028827/