Novel application of chelator-based bone debridement for refractory skull osteonecrosis complicated by <i>Pseudomonas aeruginosa</i> osteomyelitis.

Abstract

This case report details the treatment of a 58-year-old male patient with a complex medical history, including renal transplants, immunosuppression and anticoagulation therapy. The patient developed skull osteonecrosis complicated by <i>Pseudomonas aeruginosa</i> osteomyelitis following treatment for squamous cell carcinoma of the scalp. After multiple failed reconstructive surgeries and advanced wound care attempts, an innovative chelator-based bone debridement strategy was implemented as part of an advanced wound care plan at home. This approach led to >50% reduction in the area of bone exposure and eliminated <i>Pseudomonas aeruginosa</i> from bone cultures.