Peer-reviewed veterinary case report
Novel arylazoarylmethane as potential inhibitor of macrophage migration inhibitory factor.
- Journal:
- Archiv der Pharmazie
- Year:
- 2014
- Authors:
- He, Mingzhu et al.
- Affiliation:
- Center for Molecular Innovation · United States
Abstract
Macrophage migration inhibitory factor (MIF), a cytokine involved in the pathogenesis of sepsis, diabetes, asthma, arthritis, and cancer, has an enzymatic active site that has proven to be an effective target for small molecule-based inhibitors. Herein, we describe the synthesis of a novel arylazoarylmethane compound (3) from a known arylhydrazone MIF inhibitor (2). This new compound has improved stability and in vivo biological activity.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24243226/