Peer-reviewed veterinary case report
Novel class of hybrid natural products as antidiabetic agents.
- Journal:
- Natural product research
- Year:
- 2009
- Authors:
- Raj, Kanwal et al.
- Affiliation:
- Central Drug Research Institute · India
- Species:
- rodent
Abstract
A number of O-alkylated xanthone, carbazoles and coumarins have been synthesised and screened for their in vitro anti-diabetic activity, such as glucose-6-phosphatase, glycogen phosphorylase and alpha glucosidase inhibitors. Compounds which were showing significant percentage inhibition were also tested for in vivo anti-hyperglycemic activity in sucrose loaded normal and streptozotocin (STZ)-induced diabetic rats. These compounds show 22.1, 24.4 and 26.7% and 20.8, 25.0, 20.5% lowering in sucrose loaded normal rats and STZ-induced diabetic rats at a dose of 100 mg kg(-1).
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19140071/