Peer-reviewed veterinary case report
New cyclovirus found in dogs with bloody diarrhea
By Gainor, Kerry et al.·Published in Viruses·2021·Department of Biomedical Sciences·View original on PubMed →
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Original publication title: Novel Cyclovirus Species in Dogs with Hemorrhagic Gastroenteritis.
- Species:
- dog
Plain-English summary
A group of dogs on the Caribbean island of Nevis was diagnosed with hemorrhagic gastroenteritis, a serious condition that causes severe vomiting and diarrhea. Researchers found a new type of virus called cyclovirus in some of the dogs' fecal samples, which may be linked to their illness. Although it’s unclear if the dogs got the virus from their food or another source, this is the first time these cycloviruses have been identified in domestic dogs. Understanding this virus could help veterinarians better manage cases of hemorrhagic gastroenteritis in dogs.
People also search for: dog vomiting diarrhea treatment · hemorrhagic gastroenteritis in dogs · cyclovirus in dogs
Abstract
Nested PCRs with circovirus/cyclovirus pan-(replicase gene) primers detected eukaryotic circular Rep-encoding single-stranded DNA (CRESS DNA) viruses in three (samples CN9E, CN16E and CN34) of 18 canine parvovirus-2-positive fecal samples from household dogs with hemorrhagic gastroenteritis on the Caribbean island of Nevis. The complete genomes of CRESS DNA virus CN9E, CN16E and CN34 were determined by inverse nested PCRs. Based on (i) genome organization, (ii) location of the putative origin of replication, (iii) pairwise genome-wide sequence identities, (iv) the presence of conserved motifs in the putative replication-associated protein (Rep) and the arginine-rich region in the amino terminus of the putative capsid protein (Cp) and (v) a phylogenetic analysis, CN9E, CN16E and CN34 were classified as cycloviruses. Canine-associated cycloviruses CN16E and CN34 were closely related to each other and shared low genome-wide nucleotide (59.642-59.704%), deduced Rep (35.018-35.379%) and Cp (26.601%) amino acid sequence identities with CN9E. All the three canine-associated cycloviruses shared < 80% genome-wide pairwise nucleotide sequence identities with cycloviruses from other animals/environmental samples, constituting two novel species (CN9E and CN16E/34) within the genus. Considering the feeding habits of dogs, we could not determine whether the cycloviruses were of dietary origin or infected the host. Interestingly, the CN9E putative Rep-encoding open reading frame was found to use the invertebrate mitochondrial genetic code with an alternative initiation codon (ATA) for translation, corroborating the hypothesis that cycloviruses are actually arthropod-infecting viruses. To our knowledge, this is the first report on the detection and complete genome analysis of cycloviruses from domestic dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34834961/