Peer-reviewed veterinary case report
Novel Epigenetic Regulation of Alpha-Synuclein Expression in Down Syndrome.
- Journal:
- Molecular neurobiology
- Year:
- 2016
- Authors:
- Ramakrishna, Narayan et al.
- Affiliation:
- Department of Molecular Biology · United States
- Species:
- rodent
Abstract
Alpha-synuclein (SNCA), a presynaptic protein, is significantly reduced in individuals with Down syndrome (DS) and Ts65Dn mice, a mouse model of DS. Methylation analyses of promoter proximal CpG sites indicate similar reduction in Ts65Dn mice compared to control mice. Epigallocatechin-3-gallate (EGCG), a polyphenolic catechin present in green tea extract, increases methylation of SNCA promoter proximal CpG sites and expression in Ts65Dn mice. These results suggest a positive link between CpG methylation and SNCA expression in Down syndrome.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25416858/