Peer-reviewed veterinary case report
Novel Molecules To Treat Chronic Central Nervous System Toxoplasmosis.
- Journal:
- Journal of medicinal chemistry
- Year:
- 2017
- Authors:
- Kortagere, Sandhya
- Affiliation:
- Department of Microbiology and Immunology · United States
Abstract
A major challenge in treating toxoplasmosis in immunocompromised patients is lack of therapeutic agents to clear chronic infection and stop the recrudescence of infection after therapy. CDKP1 has emerged as a novel target for treating chronic infections and eliminating latent bradyzoites in the brain. In a mouse model of toxoplasmosis, pyrazolopyrimidine inhibitors of Toxoplasma gondii CDPK1 demonstrated in vitro and in vivo efficacy.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29200288/