Peer-reviewed veterinary case report
NP protein and F protein of pigeon paramyxovirus type 1 are associated with its low pathogenicity in chickens.
- Journal:
- Archives of virology
- Year:
- 2019
- Authors:
- Song, Yang et al.
- Affiliation:
- College of Veterinary Medicine · China
Abstract
In this study, we investigated which structural proteins of pigeon paramyxovirus type 1 (PPMV-1) are responsible for its low pathogenicity in chickens. The results revealed that the pathogenicity of the virus is determined by multiple genes. The NP protein and F protein were found to have the strongest individual effect on virulence, and this effect further enhanced when the two proteins were expressed in combination. Our study highlights the influence of the NP and F proteins on the pathogenicity of PPMV-1 in chickens.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31286221/