Peer-reviewed veterinary case report
NT-pro-BNP and troponin I predict death risk in dogs with heart
By Noszczyk-Nowak, A·Published in Polish journal of veterinary sciences·2011·Department of Internal Disease with Horses·View original on PubMed →
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Original publication title: NT-pro-BNP and troponin I as predictors of mortality in dogs with heart failure.
- Species:
- dog
Plain-English summary
A group of dogs with dilated cardiomyopathy (DCM), a serious heart condition, was studied to see how certain blood tests could predict their chances of survival. The researchers found that dogs with higher levels of NT-pro-BNP and troponin I (cTnI) in their blood had a much shorter lifespan, with many dying within 60 days. In fact, the dogs that lived longer than 60 days had significantly lower levels of these markers. This suggests that measuring NT-pro-BNP and cTnI can help veterinarians assess the prognosis for dogs with heart failure due to DCM.
People also search for: dog heart failure symptoms · dilated cardiomyopathy in dogs · NT-pro-BNP test for dogs
Abstract
The purpose of this study was to develop prognostic models for heart failure in dogs with dilated cardiomyopathy (DCM). The prospective study included 26 dogs with DCM and 58 healthy dogs. The ervation time median was 250 days (1-600 days). All the dogs were clinically examined, had echocardiography, electrocardiography, and morphological and biochemical blood sampling. Twenty four deaths were found in the group of dogs with DCM and 1 demise in the healthy dog's group. There was a significant increase in the level of NT-pro-BNP and cTnI (p < 0.0005) in the group of dogs with DCM and a significant higher level of NT-pro-BNP and cTnI (p < 0.0005) in the dead dogs from group with DCM that died or were euthanized up to the 60th day of observation, compared to the animals that outlasted over 60 days of observation. The median level of NT-pro-BNP in the dogs which had short survival period (no more than 60 days) was 4865 pmol/L and the median level of cTnI in the same group of dogs was 0.63 ng/ml. The median level of NT-pro-BNP in the group of dogs with DCM, which lived longer than 60 days of observation was 978 pmol/l and the median level of cTnI in this group was 0.1 ng/ml. The level of NT-pro-BNP (r = 0.79) and cTnI (r = 0.4) correlated with the dogs' death. NT-pro-BNP and cTnI measurements could be useful to evaluate the survival the dogs with DCM. Increased level of NT-pro-BNP and cTnI is a bad prognosis. In the performed analysis of the Cox hazard regression it was found that cTnI level has a significant impact of the survival of the dogs (HR = 8.54; Cl 1.1-46.6; p = 0.02).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22439324/