Peer-reviewed veterinary case report
Blood test levels linked to pulmonary hypertension in dogs
By Kellihan, Heidi B et al.·Published in Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2011·Department of Medicine, United States·View original on PubMed →
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Original publication title: NT-proBNP, NT-proANP and cTnI concentrations in dogs with pre-capillary pulmonary hypertension.
- Species:
- dog
Plain-English summary
A group of 12 dogs with pre-capillary pulmonary hypertension (PH) had significantly higher levels of a specific blood marker called NT-proBNP compared to 8 control dogs with respiratory disease but no PH. This suggests that measuring NT-proBNP could help veterinarians assess the severity of PH in dogs. However, two other markers, NT-proANP and cTnI, did not show significant differences between the two groups. Understanding these markers can help in diagnosing and managing dogs with breathing problems related to heart issues.
People also search for: dog breathing problems · pulmonary hypertension in dogs · NT-proBNP test for dogs
Abstract
OBJECTIVES: To compare [NT-proBNP], [NT-proANP] and [cTnI] between control dogs with respiratory disease without pulmonary hypertension (PH) and dogs with pre-capillary PH, and to assess the accuracy of [NT-proBNP], [NT-proANP], [cTnI] to predict Doppler-derived peak tricuspid regurgitation (TR) gradient. ANIMALS: 20 dogs. 8 control dogs with respiratory disease with no PH and 12 with pre-capillary PH. METHODS: [NT-proBNP], [NT-proANP] and [cTnI] were compared between the 2 groups and simple linear regression analysis was used to predict peak TR gradients from various blood biomarkers. RESULTS: Median [NT-proBNP] was higher in the dogs with PH (2011 pmol/L, 274-7713 pmol/L) compared to control dogs (744 pmol/L; 531-2710 pmol/L) (p = 0.0339). [NT-proBNP] was associated with peak TR gradient (R(2) = 0.7851, p = 0.0001). Median [NT-proANP] did not differ between dogs with PH (1747 fmol/L; 894-2884 fmol/L) and control dogs (1209 fmol/L; 976-1389 fmol/L (p = 0.058). [NT-proANP] was not associated with peak TR gradient (R(2) = 0.2780, p = 0.0781). Median [cTnI] did not differ between dogs with PH (0.2850 ng/mL; 0.19-1.13 ng/mL) and control dogs (0.2 ng/mL; 0.19-0.82 ng/mL, p = 0.3051). Median [TnI] was not associated with peak TR gradient (R(2) = 0.024, p = 0.6307). CONCLUSIONS: [NT-proBNP] concentration is significantly higher in dogs with pre-capillary PH when compared to dogs with respiratory disease without PH, and [NT-proBNP] may be useful to predict the severity of estimated PH. Elevations in [NT-proBNP] due to pre-capillary PH may complicate the interpretation of [NT-proBNP] elevations in patients presenting with cardiorespiratory abnormalities. [NT-proANP] and [cTnI] were not elevated in dogs with pre-capillary PH.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21835711/