Peer-reviewed veterinary case report
Nuclear morphometry in cytopathology: a prognostic indicator for canine cutaneous mast cell tumors.
- Journal:
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
- Year:
- 2009
- Authors:
- Strefezzi, Ricardo de Francisco et al.
- Affiliation:
- Departamento de Patologia · Brazil
- Species:
- dog
Abstract
Twenty-nine canine cutaneous mast cell tumors (MCTs) were morphometrically analyzed with regard to mean nuclear area (MNA) using cytopathology smears. The results showed a correlation between MNA and survival. When graded into 2 morphometrically different groups, there were statistically significant differences among high- and low-grade MCTs, regarding both Romanowsky-type stain and hematoxylin and eosin. Cytomorphometry could also separate histologic grade II tumors with better prognosis from the more aggressive MCTs. The results indicated that nuclear morphometry on cytopathology preparations can predict the biological behavior of cutaneous MCTs in dogs in an independent manner, yielding a rapid and reproducible diagnosis, which renders the method useful for veterinary oncology.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19901282/