Peer-reviewed veterinary case report
How obesity changes gene activity in cat fat and muscle
By Kathrine Stenberg et al.·Published in Journal of animal physiology and animal nutrition·2023·View original on Semantic Scholar →
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Original publication title: Obesity-induced changes in gene expression in feline adipose and skeletal muscle tissue.
- Species:
- cat
Plain-English summary
A group of indoor cats, particularly domestic shorthaired breeds, were studied to understand how obesity affects their health. These cats were found to have changes in gene expression related to fat and muscle tissue, which can impact insulin sensitivity and increase the risk of diabetes. The research showed that as cats became more obese, certain genes linked to fat metabolism decreased, while others related to muscle increased. Interestingly, there was no evidence of inflammation in the tissues, suggesting that obesity in cats might not be driven by inflammation as seen in humans. More research is needed to fully understand the causes of obesity in cats and its health implications.
People also search for: why is my cat gaining weight · cat diabetes symptoms · indoor cat obesity prevention
Abstract
Indoor-confined cats are prone to developing obesity due to a sedentary life and an energy intake exceeding energy requirements. As in humans, feline obesity decreases insulin sensitivity and increases the risk of developing feline diabetes mellitus, but the pathophysiological mechanisms are currently poorly understood. Human obesity-related metabolic alterations seem to relate to changes in the expression of genes involved in glucose metabolism, insulin action and inflammation. The objective of the current study was to investigate changes in the expression of genes relating to obesity, glucose metabolism and inflammation in cats with non-experimentally induced obesity. Biopsies from the sartorius muscle and subcutaneous adipose tissue were obtained from 73 healthy, neutered, indoor-confined domestic shorthaired cats ranging from lean to obese. Quantification of obesity-related gene expression levels relative to glyceraldehyde-3-phosphate dehydrogenase was performed by quantitative real-time polymerase chain reaction. A negative association between obesity and adiponectin expression was observed in the adipose tissue (mean ± SD; normal weight, 27.30 × 10-3 ± 77.14 × 10-3 ; overweight, 2.89 × 10-3 ± 0.38 × 10-3 and obese, 2.93 × 10-3 ± 4.20 × 10-3 , p < 0.05). In muscle, the expression of peroxisome proliferative activated receptor-γ2 and plasminogen activator inhibitor-1 was increased in the obese compared to the normal-weight cats, and resistin was increased in the normal-weight compared to the overweight cats. There were no detectable obesity-related changes in the messenger RNA levels of inflammatory cytokines. In conclusion, a possible obesity-related low-grade inflammation caused by increased expression of key proinflammatory regulators was not observed. This could imply that the development of feline obesity and ensuing insulin resistance may not be based on tissue-derived inflammation, but caused by several determining factors, many of which still need further investigation.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/36591865