Peer-reviewed veterinary case report
Ocular disease in horses with confirmed ocular or central nervous system Borrelia infection: Case series and review of literature.
- Journal:
- Veterinary ophthalmology
- Year:
- 2020
- Authors:
- Scherrer, Nicole M et al.
- Affiliation:
- University of Pennsylvania School of Veterinary Medicine · United States
- Species:
- horse
Plain-English summary
This study looked at five horses that had eye problems linked to a type of bacteria called Borrelia burgdorferi, which is known to cause Lyme disease. All the horses showed signs of inflammation in their eyes when they were examined. For two of the horses, treatment with anti-inflammatory medications helped control their eye inflammation, but one horse did not improve with oral antibiotics aimed at treating the infection. Unfortunately, four of the horses had to be euthanized because their neurological issues got worse, while one horse that had its eye removed did not show any other health problems. Overall, the study suggests that Lyme disease should be considered as a possible cause of eye issues in horses, but the outlook for recovery from both eye and neurological problems related to this infection is not good.
Abstract
OBJECTIVE: To describe the clinical presentation, treatment, and clinical outcome of horses with ocular disease and evidence of systemic or ocular Lyme disease. ANIMALS STUDIED: Five horses met the inclusion criteria of ocular disease with evidence of B burgdorferi present in ocular or CNS tissues. PROCEDURE: The goal of this study was to describe the clinical presentation and progression of ocular disease when associated with ocular or CNS B burgdorferi infection in horses. A retrospective review of medical records was performed on horses admitted for ocular disease with evidence of B burgdorferi infection between 1998 and 2015. The diagnosis of B burgdorferi-associated uveitis was based on histopathologic lesions of lymphohistiocytic and suppurative uveitis/endophthalmitis and intralesional argyrophilic spirochetes in either ocular or CNS tissue consistent with Borrelia. Leptospiral uveitis was ruled out by PCR. RESULTS: All five horses in the current study had intraocular inflammation at the time of presentation. Medical management with anti-inflammatories was successful in controlling uveitis in the two horses in which treatment of uveitis was attempted. Systemic treatment with oral tetracyclines was unsuccessful in a single case in which treatment of Borrelia was attempted. Four horses were euthanized due to progression of neurologic disease. The surviving horse had an enucleation performed and did not show systemic signs. CONCLUSIONS: Infection with Borrelia burgdorferi should be considered in endemic areas as a differential for horses with ocular disease, in particular, uveitis. The prognosis for uveitis and neurologic disease associated with Lyme disease was poor in the current study.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32862516/