Peer-reviewed veterinary case report
Poodle with brain tumor causing nervous system symptoms and rapid
By Galán, A et al.·Published in Veterinary and comparative oncology·2010·Department of Animal Medicine and Surgery, Spain·View original on PubMed →
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Original publication title: Oligodendroglial gliomatosis cerebri in a poodle.
- Species:
- dog
Plain-English summary
A 6-year-old male Poodle was brought in with symptoms affecting his central nervous system, which included neurological issues. Imaging tests showed unusual brain density and fluid tests indicated high protein levels. Unfortunately, the dog's condition worsened quickly, leading to the decision to euthanize him. A post-mortem examination revealed a rare brain tumor called oligodendroglial gliomatosis cerebri. This case is significant as it is the first reported instance of this type of tumor in dogs.
People also search for: dog brain tumor symptoms · Poodle neurological problems · gliomatosis cerebri in dogs
Abstract
Gliomatosis cerebri (GC) is a rare, diffusely infiltrating, glial cell tumour of neuroepithelial origin. This report describes a case of oligodendroglial GC in a 6-year-old male Poodle with central nervous system symptoms. Computed tomography revealed anomalous parenchyma density and ventricular asymmetry. Cerebrospinal fluid showed elevated protein (30 mg dL(-1)) and nucleated cell count (20 µL(-1)). Presumptive diagnosis of necrotizing meningoencephalitis was made. Because of rapid deterioration of the general condition of the animal, the dog was euthanized. Histologically there was an infiltration of round or ovoid neoplastic cells in the white matter of the left cerebral hemisphere and in leptomeninges. Immunohistochemistry showed that 80% of the neoplastic cells expressed Olig2 and some 50% expressed glial fibrilary acidic protein. On the basis of clinical, histological and immunohistochemical features, a diagnosis of oligodendoglial GC was done. This case represents the first report of a case of oligodendroglial GC in the canid.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21062407/