Peer-reviewed veterinary case report
Brain tumor with cartilage-like tissue in a French bulldog
By Yoshida, Kio et al.·Published in The Journal of veterinary medical science·2025·Graduate School of Agricultural and Life Sciences, Japan·View original on PubMed →
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Original publication title: Oligosarcoma with chondroid metaplasia in a French bulldog.
- Species:
- dog
Plain-English summary
A 5-year-old neutered female French bulldog was diagnosed with a brain tumor after showing symptoms that led to surgery. The tumor was removed and found to have both brain and cartilage-like cells, which is unusual. The surgery was successful, and the dog was treated for the tumor. While the details of her recovery weren't specified, the surgery indicates that the condition was addressed.
People also search for: French bulldog brain tumor symptoms · dog surgery for brain mass · oligosarcoma treatment in dogs
Abstract
A 5-year-4-month-old neutered female French bulldog had a brain mass that was surgically excised. Histologically, the tumor consisted of neoplastic oligodendroglial and spindle-shaped cells, and chondroid tissues. Immunohistochemically, oligodendroglial cells were immunopositive for oligodendrocyte transcription factor 2 (OLIG2), 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), platelet-derived growth factor receptor alpha (PDGFRA), vimentin, cluster of differentiation 44 (CD44), and WW domain containing transcription regulator 1 (WWTR1). Spindle-shaped cells were immunopositive for OLIG2, vimentin, CD44, and WWTR1. In chondroid tissues, chondrocyte-like cells were immunopositive for OLIG2, PDGFRA, vimentin, and WWTR1. In the present case, the tumor had oligodendroglial features accompanied by mesenchymal and chondroid metaplasia. Based on these findings, the dog was diagnosed with an oligosarcoma with chondroid metaplasia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40074344/