Peer-reviewed veterinary case report
Omeprazole treatment for vomiting dog with gastrinoma
By Brooks, D & Watson, G L·Published in Journal of veterinary internal medicine·1997·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Omeprazole in a dog with gastrinoma.
- Species:
- dog
Plain-English summary
A 9-year-old male German Shepherd was brought in for severe vomiting, watery diarrhea, loss of appetite, and significant weight loss. Despite treatment with other medications, the dog continued to have serious symptoms, including vomiting blood. After further tests and surgery, the vet found tumors that were causing excessive gastrin production, leading to a condition called Zollinger-Ellison syndrome. The dog was treated with omeprazole, which successfully resolved all symptoms, and he has been healthy and symptom-free for two years since the treatment.
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Abstract
A 9-year-old male German Shepherd Dog was presented with the primary complaints of vomiting, profuse watery diarrhea, anorexia, and severe weight loss. The dog developed hematemesis and melena, which were unresponsive to treatment with an H2-receptor antagonist and a gastrointestinal protectant. A marked neutrophilia, panhypoproteinemia, hypokalemia, and mildly increased activities of alkaline phosphatase and alanine aminotransferase were the only relevant abnormalities found on a CBC, serum biochemical profile, and urinalysis. An exploratory laparotomy revealed several small nonresectable masses at the root of the mesentery, which were identified histologically as a neuroendocrine neoplasm. Immunohistochemical staining of the neoplasm was positive for gastrin and negative for insulin, glucagon, pancreatic polypeptide, and vasoactive intestinal polypeptide. Fasting serum gastrin concentrations were high. Zollinger-Ellison syndrome was diagnosed, and the dog was treated with omeprazole, an H+,K(+)-ATPase inhibitor. All clinical signs resolved, and the dog remains asymptomatic 2 years later. Omeprazole may be the gastric acid antisecretory drug of choice for dogs with gastrinoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/9470166/