Peer-reviewed veterinary case report
On-demand microglia deliver the therapeutic payload in Alzheimer's disease.
- Journal:
- Cell stem cell
- Year:
- 2025
- Authors:
- Thanos, Jessica M & Lukens, John R
- Affiliation:
- Department of Neuroscience · United States
Abstract
In this issue, Chadarevian et al. showed that engraftment of human iPSC-derived microglia (iMG) engineered to express secreted neprilysin (sNEP) under the plaque-responsive CD9 promoter reduces amyloid burden, neuronal damage, and inflammation in an Alzheimer's disease (AD) mouse model.These findings establish a cell-based strategy to treat neurological diseases.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40480204/