Peer-reviewed veterinary case report
Salivary gland cancer in a 3-year-old Dachshund dog
By Nakahira, Rei et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2017·School of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Oncocytic carcinoma of the salivary gland in a dog.
- Species:
- dog
Plain-English summary
A 3-year-old male miniature Dachshund was brought to the vet because of a small mass in his jaw that grew significantly over 14 months. The mass was found to be an oncocytic carcinoma, a type of cancer affecting the salivary gland. Unfortunately, the cancer had spread to a nearby lymph node. Treatment options for this type of cancer can vary, and it's important for pet owners to discuss the best approach with their veterinarian.
People also search for: dog jaw mass treatment · Dachshund salivary gland cancer · dog cancer symptoms
Abstract
A 3-y-old male miniature Dachshund was presented with an ~0.8 cm diameter mass in the right mandibular region. Fourteen months later, the mass was 5 × 4 × 3 cm. Grossly, the mass was encapsulated and was homogeneously gray-white on cut surface. Microscopically, the mass was composed of large, round to polygonal tumor cells that were arranged in solid nests and cords separated by a fibrovascular stroma. Tumor cells had large, round, hypochromatic nuclei containing large prominent nucleoli and abundant eosinophilic cytoplasm containing dark blue granules visible with phosphotungstic acid-hematoxylin stain. Metastasis was observed in the mandibular lymph node. Immunohistochemically, tumor cells were positive for CK AE1/AE3, low-molecular-weight CK (CAM5.2), E-cadherin, mitochondria ATPase beta subunit, and S100, but were negative for vimentin, carcinoembryonic antigen, p63, CK14, CD10, and chromogranin A. Ultrastructurally, tumor cells contained numerous mitochondria. Therefore, the tumor was diagnosed as an oncocytic carcinoma of the mandibular gland.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28074714/