Peer-reviewed veterinary case report
Oncolytic virus therapy for dog cancer - what to know
By Patil, Sandeep S et al.·Published in Journal of translational medicine·2012·Department of Biochemistry, Germany·View original on PubMed →
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Original publication title: Oncolytic virotherapy in veterinary medicine: current status and future prospects for canine patients.
- Species:
- dog
Plain-English summary
Oncolytic viruses are special viruses that can target and destroy cancer cells while leaving healthy cells alone. In dogs, researchers have tested several types of these viruses, like adenovirus strains and canine distemper virus, to treat cancer in lab studies. However, there haven't been any clinical trials in dogs like there have been in humans, so we still don't know which virus would work best. This review looks at the potential for using oncolytic viruses to treat tumors in dogs, which could help develop new treatments for canine cancer in the future. Overall, while the research is promising, we are still in the early stages of finding effective therapies for dogs with cancer.
Abstract
Oncolytic viruses refer to those that are able to eliminate malignancies by direct targeting and lysis of cancer cells, leaving non-cancerous tissues unharmed. Several oncolytic viruses including adenovirus strains, canine distemper virus and vaccinia virus strains have been used for canine cancer therapy in preclinical studies. However, in contrast to human studies, clinical trials with oncolytic viruses for canine cancer patients have not been reported. An 'ideal' virus has yet to be identified. This review is focused on the prospective use of oncolytic viruses in the treatment of canine tumors - a knowledge that will undoubtedly contribute to the development of oncolytic viral agents for canine cancer therapy in the future.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22216938/