Peer-reviewed veterinary case report
One-year immunity in dogs after Lyme disease vaccination
By LaFleur, Rhonda L et al.·Published in Clinical and vaccine immunology : CVI·2010·Intervet/Schering-Plough Animal Health Corporation, United States·View original on PubMed →
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Original publication title: One-year duration of immunity induced by vaccination with a canine Lyme disease bacterin.
- Species:
- dog
Plain-English summary
A group of beagles was vaccinated against Lyme disease and then exposed to infected ticks a year later. The vaccinated dogs showed significantly less infection and did not develop joint problems or symptoms associated with Lyme disease, while many of the dogs that received a placebo did. The vaccine provided strong protection for a full year, especially when enhanced with a specific strain of the bacteria. This suggests that vaccination is an effective way to protect dogs from Lyme disease.
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Abstract
Laboratory-reared beagles were vaccinated with a placebo or a bacterin comprised of Borrelia burgdorferi S-1-10 and ospA-negative/ospB-negative B. burgdorferi 50772 and challenged after 1 year with B. burgdorferi-infected Ixodes scapularis ticks. For the placebo recipients, spirochetes were recovered from 9 (60%) skin biopsy specimens collected after 1 month, and the organisms persisted in the skin thereafter. Ten (67%) dogs also developed joint infection (3 dogs), lameness or synovitis (7 dogs), or B. burgdorferi-specific antibodies (8 dogs). For the vaccine recipients, spirochetes were recovered from 6 (40%) skin biopsy specimens collected after 1 month. However, subsequent biopsy specimens were negative, and the dogs failed to develop joint infection (P = 0.224), lameness/synovitis (P = 0.006), or Lyme disease-specific antibody responses (P = 0.002). The bacterin provided a high level of protection for 1 year after immunization, and the addition of the OspC-producing B. burgdorferi 50772 provided enhanced protection.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20237200/