Peer-reviewed veterinary case report
How fast and how long does lokivetmab stop itching in dogs
By Fleck, Timothy J et al.·Published in Veterinary dermatology·2021·Veterinary Medicine Research & Development, United States·View original on PubMed →
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Original publication title: Onset and duration of action of lokivetmab in a canine model of IL-31 induced pruritus.
- Species:
- dog
Plain-English summary
A group of beagle dogs with itching caused by allergic reactions were treated with a medication called lokivetmab (Cytopoint) to see how quickly it worked and how long the relief lasted. The dogs received a single injection of lokivetmab, and within just 3 hours, they showed a significant decrease in itching. The effects lasted for up to 42 days, depending on the dose given. This means that lokivetmab can be an effective option for managing itching in dogs for an extended period after just one treatment.
People also search for: dog itching treatment · Cytopoint for dogs · how long does lokivetmab last
Abstract
BACKGROUND: Interleukin (IL)-31 is a cytokine involved in allergic inflammation which induces pruritus across species including dogs. Using recombinant canine IL-31 we have developed a model of pruritus in the dog to evaluate onset of action and duration of effect of therapeutic drugs. OBJECTIVE: To assess the onset of action and duration of effect of lokivetmab (Cytopoint) in the IL-31-induced pruritus model. ANIMALS: Twenty-four purpose-bred beagle dogs (neutered males, spayed and intact females) 1.5-4.7 years old and weighing between 6 and14 kg. METHODS AND MATERIALS: Randomized, blinded, placebo-controlled studies were designed to evaluate the antipruritic properties of lokivetmab. Laboratory beagle dogs were given either placebo, 0.125, 0.5 or 2.0 mg/kg lokivetmab, subcutaneously. IL-31 then was administered to evaluate pruritus 3-5 h post-placebo or -lokivetmab administration as well as one, seven, 14, 28, 42 and 56 days post-dosing. Pruritus was evaluated over a 2 h window in animals by video monitoring and scored using a categorical scoring system. RESULTS: When animals were given 2.0 mg/kg lokivetmab, a significant reduction in pruritus was observed at 3-4, 4-5 and 3-5 h post-treatment (P ≤ 0.0001). When animals were given either 0.125, 0.5 or 2 mg/kg lokivetmab, the duration of effect was dose-dependent and statistically significant for 14, 28 and 42 days, respectively (P ≤ 0.0288). CONCLUSION: These data indicate that a single subcutaneous injection of 2 mg/kg lokivetmab produces a significant suppression of pruritus starting 3 h post-treatment that can be sustained for 42 days.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33830571/