Peer-reviewed veterinary case report
Opiate-antagonist reversal of neurological deficits--experimental and clinical studies.
- Journal:
- The Japanese journal of psychiatry and neurology
- Year:
- 1986
- Authors:
- Namba, S et al.
- Species:
- dog
Plain-English summary
In a study involving 12 adult dogs, researchers tested a treatment to help improve movement and brain function after certain nerves were clipped. They injected a medication called naloxone into half of the dogs, but it didn't change their blood pressure or blood flow in the brain. In another group of dogs that had trouble moving one side of their body for a long time, naloxone helped improve their movement somewhat. Additionally, eight dogs with different neurological issues were given a different medication called levallorphan, which seemed to help most of them feel more alert and improve their motor skills, except for two dogs. Overall, the treatments showed some positive effects on movement and brain activity.
Abstract
The proximal left M1 and the common trunk of A2 were clipped in 12 adult dogs. Naloxone was injected after placing the clips onto 6 dogs. Neither the systemic blood pressure nor the local cerebral blood flow were influenced by naloxone. In another group of 6 dogs with chronic right hemiplegia, naloxone proved passably effective in improving the hemiplegia. Eight patients with neurological deficits of various etiologies were administered levallorphan. The improvement in motor performance and/or elevation of mental activity was observed more or less in all but 2 of the patients. It was considered that the effect of opiate antagonists is based partially on the facilitation of synaptic transmission exaggerated by the arousal response.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/3773354/