Peer-reviewed veterinary case report
Opposite effects of neonatal hypoxia on acute amphetamine-induced hyperlocomotion in adult and adolescent mice.
- Journal:
- Psychiatry research
- Year:
- 2013
- Authors:
- Kameda, Sonia R et al.
- Affiliation:
- Department of Pharmacology · Brazil
- Species:
- rodent
Abstract
We investigated whether the effect of neonatal hypoxia on amphetamine-induced hyperlocomotion can reproduce the ontogenic (age of onset) properties of schizophrenia. Neonatal hypoxia enhanced amphetamine-induced hyperlocomotion in adult mice and decreased it in adolescent mice. These findings provide ontogenic validity for this very simple animal model of schizophrenia.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23618352/