Peer-reviewed veterinary case report
Optic Nerve Crush Injury in Rodents to Study Retinal Ganglion Cell Neuroprotection and Regeneration.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2023
- Authors:
- Ahmed, Zubair
- Affiliation:
- Institute of Inflammation and Ageing · United Kingdom
Abstract
Optic nerve crush injury is a useful model for studying the response of central nervous system neurons (CNS) to injury. A particular focus of this model has been to elucidate therapeutic factors in promoting neuroprotection and axon regeneration after injury. Here we describe a step-by-step protocol in accessing the optic nerve and creating a crush injury. This can be used to create a reproducible model to study the response of retinal ganglion cells (RGC), the main projection neurons of the eye, to injury.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/37558963/