Peer-reviewed veterinary case report
Optical imaging of removed anal sac tumors in dogs
By Dornbusch, Josephine A et al.·Published in Veterinary and comparative oncology·2021·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Optical coherence tomography imaging of excised canine apocrine gland anal sac adenocarcinoma tumours.
- Species:
- dog
Plain-English summary
A group of five dogs with anal sac tumors called apocrine gland anal sac adenocarcinoma (AGASACA) had their excised tissue examined using a special imaging technique called optical coherence tomography (OCT). This method was able to detect the tumors very close to the edges of the surgical margins, which is important for ensuring all cancerous tissue is removed during surgery. The results showed that OCT could effectively identify AGASACA, similar to its previous use for other types of tumors in dogs. This suggests that OCT might be a useful tool for veterinarians in the future to help ensure complete tumor removal during surgeries.
People also search for: dog anal sac tumor treatment · apocrine gland anal sac adenocarcinoma in dogs · optical coherence tomography for dog tumors
Abstract
Optical coherence tomography (OCT) is an optical imaging modality that has been investigated for real-time surgical margin evaluation in human breast cancer patients. Previous veterinary OCT studies have been limited to surgical margin imaging for soft tissue sarcoma (STS) tumours. To the authors knowledge, OCT has never been used to characterize or evaluate other types of neoplasia in dogs. The goal of this study was to characterize the OCT imaging appearance of apocrine gland anal sac adenocarcinoma (AGASACA) in excised ex vivo specimens from five client-owned dogs. All excised tissue surgical margins were imaged using a clinical spectral domain OCT system and two to four areas suspicious for incomplete surgical margins were selected. These areas were inked and sections were trimmed for histopathology. This enabled OCT imaging from each area of interest to be compared with corresponding H&E stained histology imaging from the same location. OCT was able to identify the presence of AGASACA at or within 1 mm of the surgical margin in all areas of interest. AGASACA, similar to the previously described canine STS, generated a dense, highly scattering image without any specific textural architecture. This study was able to validate the ability of OCT to accurately identify another type of tumour presence at or close to the surgical margin in the dog. Further study is needed to assess OCT accuracy at identifying other tumour types in dogs to understand its potential clinical applications.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32562302/