Peer-reviewed veterinary case report
Dog with C. difficile diarrhea treated successfully with oral fecal
By Sugita, Koji et al.·Published in BMC veterinary research·2019·Cooperative Department of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Oral faecal microbiota transplantation for the treatment of Clostridium difficile-associated diarrhoea in a dog: a case report.
- Species:
- dog
Plain-English summary
An 8-month-old male French bulldog was suffering from intermittent diarrhea for four months, caused by a Clostridium difficile infection. After tests confirmed the presence of this bacteria, the dog was treated with oral fecal microbiota transplantation (FMT), where a solution from a healthy beagle was given to him. Within just 2-3 days, his stool returned to normal, and follow-up tests showed no signs of the infection. The treatment was successful, and the dog experienced no side effects.
People also search for: dog diarrhea treatment · French bulldog Clostridium difficile · fecal microbiota transplantation for dogs
Abstract
BACKGROUND: Successful clinical outcomes of faecal microbiota transplantation (FMT) for recurrent Clostridium difficile infection have been reported in humans and a marmoset. However, it has been unclear whether oral FMT was effective for the treatment of C. difficile-associated diarrhoea in dogs. CASE PRESENTATION: An 8-month-old, intact male French bulldog was presented with a 4-month history of intermittent large bowel diarrhoea. Physical and clinical examinations did not identify any specific causes for diarrhoea. Real-time PCR analysis and immunochromatography detected C. difficile antigen and toxin A&B genes and proteins in a faecal sample. Based on these findings, diarrhoea in the dog was considered to be induced by C. difficile-associated colitis. The dog was treated with oral FMT, in which a faecal solution obtained from a healthy beagle was orally administered to the subject. Stool consistency and frequency and faecal blood and mucus became normal 2-3 days after oral FMT, and real-time PCR analysis and immunochromatography was negative for C. difficile antigen and toxin A&B genes and proteins. No adverse events were observed. CONCLUSION: The present case report demonstrated that oral FMT was an effective treatment for C. difficile-associated diarrhoea in a dog. The findings in this report provide a rationale to evaluate clinical efficacy of oral FMT for other gastrointestinal diseases in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30616615/