Peer-reviewed veterinary case report
Oral immunization with Acanthamoeba castellanii mannose-binding protein ameliorates amoebic keratitis.
- Journal:
- Infection and immunity
- Year:
- 2006
- Authors:
- Garate, M et al.
- Affiliation:
- Department of Ophthalmology · United States
- Species:
- rodent
Abstract
Acanthamoeba castellanii mannose-binding protein (MBP) mediates adhesion of the amoebae to corneal epithelial cells, a key first step in the pathogenesis of Acanthamoeba keratitis (AK), a devastating corneal infection. In the present study, we demonstrate that oral immunization with recombinant MBP ameliorates AK in a hamster animal model and that this protection is associated with the presence of elevated levels of anti-MBP immunoglobulin A in the tear fluid of the immunized animals.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16982837/